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2013	Thème 2	BioFib	Martin Lenz	LPTMS	LPS	Chaire junior interne	120

Cell mechanics relies on the geometrical organization of protein filaments, and its failure is related to diseases ranging from sickle cell anemia to Alzheimer’s to cancer. Surprisingly, even in healthy cells the detailed morphology of these vital structures is very variable. To understand this paradoxical combination of reliability and randomness in the cell’s architecture, I mainly request a two-year postdoc to help me theoretically characterize robust, generic organizational principles for biofilaments on multiple scales. At the whole cell level, I plan on showing that due to symmetry constraints contractility in disordered networks of filaments and molecular motors proceeds through previously overlooked mechanisms. To understand which of these mechanisms dominates, I will then investigate the genesis of the network’s smaller-scale, out-of-equilibrium structure. Finally, I will examine fundamental issues pertaining to protein fiber formation and show that irregular protein-like particles have a natural tendency to aggregate into filaments to relieve the geometrical frustration resulting from their ill-fitting shapes.

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